Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
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A role for MHC class II antigen processing in B cell development.Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathwayAlternate interactions define the binding of peptides to the MHC molecule IA(b).Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionInvariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivoThe invariant chain is required for intracellular transport and function of major histocompatibility complex class II moleculesA role for calnexin (IP90) in the assembly of class II MHC moleculesThe segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptidesInvariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone massA p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.Pathways of antigen processing.Diminished intracellular invariant chain expression after vaccinia virus infection.Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange.Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41.Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity.Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice.EAE mediated by a non-IFN-γ/non-IL-17 pathway.Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.Inhibition of T cells provides protection against early invasive pneumococcal diseaseRole of interleukin-7 in T-cell development from hematopoietic stem cells.Diversity in MHC class II antigen presentation.Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice.Antigen presentation by keratinocytes directs autoimmune skin disease.Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.Uncovering the role of invariant chain in controlling MHC class II antigen capture.Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells.A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunityDendritic cell maturation and antigen presentation in the absence of invariant chain.Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.Assembly and peptide binding of major histocompatibility complex class II heterodimers in an in vitro translation system.Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.Comparison of predicted and actual consequences of missense mutations.The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DMNegative selection imparts peptide specificity to the mature T cell repertoire.Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity
P2860
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P2860
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
description
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1993
@ast
im Juni 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/06/01)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/06/01)
@nl
наукова стаття, опублікована в червні 1993
@uk
مقالة علمية (نشرت في يونيو 1993)
@ar
name
Defective major histocompatibi ...... ing invariant chain expression
@ast
Defective major histocompatibi ...... ing invariant chain expression
@en
Defective major histocompatibi ...... ing invariant chain expression
@nl
type
label
Defective major histocompatibi ...... ing invariant chain expression
@ast
Defective major histocompatibi ...... ing invariant chain expression
@en
Defective major histocompatibi ...... ing invariant chain expression
@nl
prefLabel
Defective major histocompatibi ...... ing invariant chain expression
@ast
Defective major histocompatibi ...... ing invariant chain expression
@en
Defective major histocompatibi ...... ing invariant chain expression
@nl
P2093
P2860
P356
P1476
Defective major histocompatibi ...... ing invariant chain expression
@en
P2093
E J Robertson
E K Bikoff
R N Germain
V Episkopou
P2860
P304
P356
10.1084/JEM.177.6.1699
P407
P577
1993-06-01T00:00:00Z