Negative selection imparts peptide specificity to the mature T cell repertoire.
about
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display libraryCrossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityDirected evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.The effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognitionThymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.Revisiting thymic positive selection and the mature T cell repertoire for antigen.Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium diseaseAutoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetesAlloreactivity is limited by the endogenous peptide repertoireOn the logic of restrictive recognition of peptide by the T-cell antigen receptor.T cell receptor specificity for major histocompatibility complex proteins.Contrasting responses to selection in class I and class IIα major histocompatibility-linked markers in salmon.Survivin-specific T cell receptor targets tumor but not T cells.The effects of thymic selection on the range of T cell cross-reactivity.Restricted MHC-peptide repertoire predisposes to autoimmunity.Functional development of the T cell receptor for antigenEvolutionarily conserved amino acids that control TCR-MHC interaction.Does intra-individual major histocompatibility complex diversity keep a golden mean?Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.MHC restriction and allogeneic immune responses.Theories and quantification of thymic selection.Basic and translational applications of engineered MHC class I proteins.A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus.A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoireInterface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide.Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection.Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.Citrullination of self-proteins and autoimmunity.Learning from the lost: new insights into TCR specificity.
P2860
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P2860
Negative selection imparts peptide specificity to the mature T cell repertoire.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Negative selection imparts peptide specificity to the mature T cell repertoire.
@ast
Negative selection imparts peptide specificity to the mature T cell repertoire.
@en
type
label
Negative selection imparts peptide specificity to the mature T cell repertoire.
@ast
Negative selection imparts peptide specificity to the mature T cell repertoire.
@en
prefLabel
Negative selection imparts peptide specificity to the mature T cell repertoire.
@ast
Negative selection imparts peptide specificity to the mature T cell repertoire.
@en
P2860
P50
P356
P1476
Negative selection imparts peptide specificity to the mature T cell repertoire.
@en
P2093
Eric S Huseby
Frances Crawford
P2860
P304
11565-11570
P356
10.1073/PNAS.1934636100
P407
P577
2003-09-22T00:00:00Z