A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell
about
DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobinT to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic miceNuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.Genome architecture of the human beta-globin locus affects developmental regulation of gene expressionThe human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin geneRole of gene order in developmental control of human gamma- and beta-globin gene expression.Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.A naturally occurring gamma globin gene mutation enhances SP1 binding activity.Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.Analysis of the mechanism of action of the Brazilian type (Agamma-195 C --> G) of hereditary persistence of fetal hemoglobin.Butyrate induces expression of transfected human fetal and endogenous mouse embryonic globin genes in GM 979 erythroleukemia cells.
P2860
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P2860
A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
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name
A fetal globin gene mutation i ...... trength in a nonerythroid cell
@en
type
label
A fetal globin gene mutation i ...... trength in a nonerythroid cell
@en
prefLabel
A fetal globin gene mutation i ...... trength in a nonerythroid cell
@en
P2860
P356
P1476
A fetal globin gene mutation i ...... trength in a nonerythroid cell
@en
P2093
R E Gelinas
P2860
P304
P356
10.1128/MCB.8.2.713
P407
P577
1988-02-01T00:00:00Z