Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions
about
Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factorS-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideSilencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's miceCdk5 regulates the organization of Nestin and its association with p35TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's diseaseA Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseNeuroprotective Mechanisms Mediated by CDK5 InhibitionCharcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilamentsAspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in cultureCalpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injuryA neurotoxic peripherin splice variant in a mouse model of ALSActivation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociationPhosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neuronsCdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptorsSIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisA NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neuronsCdk5 phosphorylates p53 and regulates its activityThe amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration.Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion diseaseBeyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathwayNo difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells.Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.Deregulation of HDAC1 by p25/Cdk5 in neurotoxicityA decade of CDK5.Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activityA 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.Neurobehavioral characteristics of mice with modified intermediate filament genes.Suppression of extensive neurofilament phosphorylation rescues α-Internexin/peripherin-overexpressing PC12 cells from neuronal cell death.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity.Cell cycle activation and spinal cord injury.Cycling at the interface between neurodevelopment and neurodegeneration.A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
P2860
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P2860
Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions
description
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im April 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/04/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/04/01)
@nl
наукова стаття, опублікована у квітні 2001
@uk
مقالة علمية (نشرت في أبريل 2001)
@ar
name
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@ast
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@en
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@nl
type
label
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@ast
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@en
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@nl
prefLabel
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@ast
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@en
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@nl
P2093
P921
P3181
P1433
P1476
Deregulation of Cdk5 in a mous ...... aryal neurofilament inclusions
@en
P2093
J. P. Julien
M. D. Nguyen
R. C. Larivière
P304
P3181
P356
10.1016/S0896-6273(01)00268-9
P407
P577
2001-04-01T00:00:00Z