A PHD finger motif in the C terminus of RAG2 modulates recombination activity
about
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRXThe plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationCompound heterozygous mutation of Rag1 leading to Omenn syndromeElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingAnalysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.Keeping it in the family: diverse histone recognition by conserved structural foldsMobilization of RAG-generated signal ends by transposition and insertion in vivoNoncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombinationReal-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tailsA plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.RAG: a recombinase diversified.PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.Role of recombination activating genes in the generation of antigen receptor diversity and beyond.Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Nuclear phosphoinositides and their impact on nuclear functions.Histone methylation and V(D)J recombination.Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures.Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways.Modeling of the RAG reaction mechanism.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance.H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.
P2860
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P2860
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
description
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im August 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/08/05)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/08/05)
@nl
наукова стаття, опублікована в серпні 2005
@uk
name
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@ast
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@en
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@nl
type
label
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@ast
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@en
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@nl
prefLabel
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@ast
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@en
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@nl
P2093
P2860
P356
P1476
A PHD finger motif in the C terminus of RAG2 modulates recombination activity
@en
P2093
Colin G. Ferguson
Dmitri Ivanov
Gerhard Wagner
Glenn D. Prestwich
Junying Yuan
Marjorie A. Oettinger
Or P. Gozani
Sheryl K. Elkin
Sven G. Hyberts
Zhen-Yu J. Sun
P2860
P304
28701–28710
P356
10.1074/JBC.M504731200
P407
P577
2005-08-05T00:00:00Z