H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.
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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayThe histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationHuman RAG mutations: biochemistry and clinical implicationsThe taming of the shrew: Regulation of a catalytically active domesticated transposaseElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingRAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.Epigenome Maintenance in Response to DNA DamageIllegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes.Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Epigenetic regulation of antigen receptor gene rearrangementThe origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombinationEpigenetic control of recombination in the immune systemAutoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationThe DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer.Regulation of TCRβ allelic exclusion by gene segment proximity and accessibilityHistone modifications predispose genome regions to breakage and translocation.Determinants of public T cell responses.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination.Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centersAssembly and Expression of Shark Ig Genes.The cellular etiology of chromosome translocations.Unifying model for molecular determinants of the preselection Vβ repertoire.Real-time analysis of RAG complex activity in V(D)J recombinationRAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2.Chromatin architecture and the generation of antigen receptor diversity.The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinaseAllelic exclusion of immunoglobulin genes: models and mechanisms.The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.
P2860
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P2860
H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
H3K4me3 stimulates the V
@nl
H3K4me3 stimulates the V(D)J R ...... plications for translocations.
@en
type
label
H3K4me3 stimulates the V
@nl
H3K4me3 stimulates the V(D)J R ...... plications for translocations.
@en
prefLabel
H3K4me3 stimulates the V
@nl
H3K4me3 stimulates the V(D)J R ...... plications for translocations.
@en
P2093
P2860
P1433
P1476
H3K4me3 stimulates the V(D)J R ...... plications for translocations.
@en
P2093
Albert G Tsai
Michael R Lieber
Noriko Shimazaki
P2860
P304
P356
10.1016/J.MOLCEL.2009.05.011
P577
2009-06-01T00:00:00Z