A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.
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The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationHistone chaperone Spt6 is required for class switch recombination but not somatic hypermutationOrigin and evolution of the adaptive immune system: genetic events and selective pressuresDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsEpigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2Mechanics of T cell receptor gene rearrangementLong-Range Regulation of V(D)J RecombinationKeep-ING balance: tumor suppression by epigenetic regulationRAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationRole of non-homologous end joining in V(D)J recombinationHuman RAG mutations: biochemistry and clinical implicationsCompound heterozygous mutation of Rag1 leading to Omenn syndromeA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingImmunoglobulin heavy chain exclusion in the sharkInitiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assemblyBinding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modificationsGenome-wide views of chromatin structureThe origins of the Rag genes--from transposition to V(D)J recombination.Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombinationAnalysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.PHD fingers: epigenetic effectors and potential drug targetsNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.High resolution analysis of the chromatin landscape of the IgE switch region in human B cellsAn autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.The origins of vertebrate adaptive immunity.Epigenetic regulation of antigen receptor gene rearrangementConserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferationRoles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombinationEpigenetic control of recombination in the immune systemChromatin remodeling, DNA damage repair and aging.Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationThe DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.
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P2860
A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 October 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@en
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@nl
type
label
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@en
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@nl
prefLabel
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@en
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@nl
P2093
P2860
P1433
P1476
A plant homeodomain in RAG-2 t ...... n-receptor-gene rearrangement.
@en
P2093
Ramesh Subrahmanyam
Ranjan Sen
Stephen Desiderio
Tirtha Chakraborty
P2860
P304
P356
10.1016/J.IMMUNI.2007.09.005
P407
P577
2007-10-11T00:00:00Z