Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
about
Role of Nrf2 in oxidative stress and toxicityParkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityDJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBThe role of oxidative stress in Parkinson's diseaseOxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitroDJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayParkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationRNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysInactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1Mitochondrial localization of DJ-1 leads to enhanced neuroprotectionDJ-1 is a copper chaperone acting on SOD1 activationDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingParkinson's Disease: The Mitochondria-Iron LinkNeuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent PerspectivesEvaluation of Models of Parkinson's DiseaseThe associations between Parkinson's disease and cancer: the plot thickensParkinson's disease proteins: Novel mitochondrial targets for cardioprotectionElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsMouse models of Parkinson's disease associated with mitochondrial dysfunctionMechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylationGenetically engineered mouse models of Parkinson's diseaseParkinson's disease, insulin resistance and novel agents of neuroprotectionGene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian modelsEmerging functional cross-talk between the Keap1-Nrf2 system and mitochondriaMitochondrial dysfunction and oxidative stress in Parkinson's diseaseIdentification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's diseaseStructural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent MannerParkinson's disease: animal models and dopaminergic cell vulnerabilityMitochondrial defects and oxidative stress in Alzheimer disease and Parkinson diseaseGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseThe Roles of Glutathione Peroxidases during Embryo DevelopmentPro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neuronsImpaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient miceDJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidaseDJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production
P2860
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P2860
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Hypersensitivity of DJ-1-defic ...... ne (MPTP) and oxidative stress
@nl
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@ast
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@en
type
label
Hypersensitivity of DJ-1-defic ...... ne (MPTP) and oxidative stress
@nl
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@ast
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@en
prefLabel
Hypersensitivity of DJ-1-defic ...... ne (MPTP) and oxidative stress
@nl
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@ast
Hypersensitivity of DJ-1-defic ...... e (MPTP) and oxidative stress.
@en
P2093
P2860
P50
P3181
P356
P1476
Hypersensitivity of DJ-1-defic ...... ne (MPTP) and oxidative stress
@en
P2093
Andres M Lozano
Andrew Wakeham
Annick J You-Ten
David Westaway
Hymie Anisman
Matthew P Mount
Patrick Horne
Raymond H Kim
Scott Pownall
Shawn Hayley
P2860
P304
P3181
P356
10.1073/PNAS.0501282102
P407
P577
2005-03-22T00:00:00Z