about
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter moleculesNitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunctionp66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosisIdentification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathwaysNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationInsulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingTumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.Identification of the rat adapter Grb14 as an inhibitor of insulin actionsThe ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryoNon-redundant role of Shc in Erk activation by cytoskeletal reorganizationNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayGi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor ShcSpatio-temporal modeling of signaling protein recruitment to EGFR.Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.Adapter protein Shc regulates Janus kinase 3 phosphorylationIntegration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation.The real Dorian Gray mouse.Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.Mechanisms of transformation by the BCR/ABL oncogene.Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes.Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells.Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway.Discovery of MicroRNAs associated with myogenesis by deep sequencing of serial developmental skeletal muscles in pigs.An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation.Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.The intersection between aging and cardiovascular disease.Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc.Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain.Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc.Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
P2860
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P2860
description
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im Juli 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/07/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/07/01)
@nl
наукова стаття, опублікована в липні 1996
@uk
مقالة علمية (نشرت في يوليو 1996)
@ar
name
Not all Shc's roads lead to Ras
@ast
Not all Shc's roads lead to Ras
@en
Not all Shc's roads lead to Ras
@nl
type
label
Not all Shc's roads lead to Ras
@ast
Not all Shc's roads lead to Ras
@en
Not all Shc's roads lead to Ras
@nl
prefLabel
Not all Shc's roads lead to Ras
@ast
Not all Shc's roads lead to Ras
@en
Not all Shc's roads lead to Ras
@nl
P2093
P1476
Not all Shc's roads lead to Ras
@en
P2093
E. Migliaccio
G. Pelicci
L. Bonfini
L. Lanfrancone
P. G. Pelicci
P304
P356
10.1016/0968-0004(96)10033-5
P577
1996-07-01T00:00:00Z