A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
about
Antiviral response in pandemic influenza virusesHerpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusInfluenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IA Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in MiceNegative regulation of cytoplasmic RNA-mediated antiviral signalingConserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B virusesStructure of the Ebola VP35 interferon inhibitory domainA Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector DomainInfluenza virus activation of the interferon systemThe interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replicationNS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IViral evasion of intracellular DNA and RNA sensingInfluenza A virus attenuation by codon deoptimization of the NS gene for vaccine developmentEssential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusMultiple anti-interferon actions of the influenza A virus NS1 proteinMolecular determinants of influenza virus pathogenesis in mice.Mutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence.Genetic characterization of avian influenza viruses isolated in Israel during 2000-2006.Development of a vaccine against pandemic influenza viruses: current status and perspectives.Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity.Induction of virus-specific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccinesAn influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner.Novel influenza virus NS1 antagonists block replication and restore innate immune function.Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIVInnate immune evasion strategies of influenza virusesThe HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.Efficacy of Live-Attenuated H9N2 Influenza Vaccine Candidates Containing NS1 Truncations against H9N2 Avian Influenza VirusesDiversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergenceDiagnostic approach for differentiating infected from vaccinated poultry on the basis of antibodies to NS1, the nonstructural protein of influenza A virus.Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.Attenuation of equine influenza viruses through truncations of the NS1 proteinInfluenza A viruses with truncated NS1 as modified live virus vaccines: pilot studies of safety and efficacy in horses.The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.Influenza A virus-generated small RNAs regulate the switch from transcription to replication.The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions.Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor.
P2860
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P2860
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
description
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Dezember 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/12/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/12/01)
@nl
наукова стаття, опублікована в грудні 2003
@uk
مقالة علمية (نشرت في ديسمبر 2003)
@ar
name
A recombinant influenza A viru ...... eron and is attenuated in mice
@ast
A recombinant influenza A viru ...... eron and is attenuated in mice
@en
A recombinant influenza A viru ...... eron and is attenuated in mice
@nl
type
label
A recombinant influenza A viru ...... eron and is attenuated in mice
@ast
A recombinant influenza A viru ...... eron and is attenuated in mice
@en
A recombinant influenza A viru ...... eron and is attenuated in mice
@nl
prefLabel
A recombinant influenza A viru ...... eron and is attenuated in mice
@ast
A recombinant influenza A viru ...... eron and is attenuated in mice
@en
A recombinant influenza A viru ...... eron and is attenuated in mice
@nl
P2860
P3181
P1433
P1476
A recombinant influenza A viru ...... eron and is attenuated in mice
@en
P2093
Nicola R Donelan
P2860
P304
13257-13266
P3181
P356
10.1128/JVI.77.24.13257-13266.2003
P577
2003-12-01T00:00:00Z