Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase.
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Enzyme Selectivity of HIV Reverse Transcriptase: Conformations, Ligands, and Free Energy PartitionStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions inB. thetaiotaomicronDNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA PolymeraseUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayAlteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamicsAssembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complexA Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantConformational dynamics of Thermus aquaticus DNA polymerase I during catalysis.Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase deltaRole of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants.Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence.Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase.Kinetic characterization of exonuclease-deficient Staphylococcus aureus PolC, a C-family replicative DNA polymerase.How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations.The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase.Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptaseEffect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity.Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide additionBiochemical mechanism of HIV-1 resistance to rilpivirine.Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase Allosterically Block the Transition from Initiation to ElongationA century of enzyme kinetic analysis, 1913 to 2013.Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases.A new general method for simultaneous fitting of temperature and concentration dependence of reaction rates yields kinetic and thermodynamic parameters for HIV reverse transcriptase specificity.Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.The mechano-chemistry of a monomeric reverse transcriptase.Pyrophosphate Release in the Protein HIV Reverse Transcriptase.Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.Mechanistic Origins of Enzyme Activation in Human Glucokinase Variants Associated with Congenital Hyperinsulinism.
P2860
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P2860
Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Nucleotide-dependent conformat ...... by HIV reverse transcriptase.
@en
type
label
Nucleotide-dependent conformat ...... by HIV reverse transcriptase.
@en
prefLabel
Nucleotide-dependent conformat ...... by HIV reverse transcriptase.
@en
P2860
P356
P1476
Nucleotide-dependent conformat ...... by HIV reverse transcriptase.
@en
P2093
Kenneth A Johnson
Matthew W Kellinger
P2860
P304
P356
10.1073/PNAS.0913946107
P407
P577
2010-04-12T00:00:00Z