Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
about
Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxelTyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growthExpression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cellsShort-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesisActivation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pitsGrb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinase.Specificity and affinity motifs for Grb2 SH2-ligand interactionsDeath effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismNeoplastic progression of breast epithelial cells--a molecular analysis.Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor.Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling.Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression.Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimersRAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimersGRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimerCollagen-homology domain 1 deletion mutant of Shc suppresses transformation mediated by neu through a MAPK-independent pathway.
P2860
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P2860
Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
description
1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1995
@ast
im Dezember 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/12/22)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/12/22)
@nl
наукова стаття, опублікована в грудні 1995
@uk
name
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@ast
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@en
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@nl
type
label
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@ast
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@en
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@nl
prefLabel
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@ast
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@en
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@nl
P2093
P2860
P356
P1476
Dominant-negative mutants of G ...... tation-activated rat HER-2/Neu
@en
P2093
A. M. Pendergast
M. C. Hung
P2860
P304
30717–30724
P356
10.1074/JBC.270.51.30717
P407
P577
1995-12-22T00:00:00Z