The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
about
Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cellsThe phosphorylation state of an autoregulatory domain controls PACS-1-directed protein trafficCripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturationFurin at the cutting edge: from protein traffic to embryogenesis and diseaseProprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseasesMolecular basis for LDL receptor recognition by PCSK9Autoproteolytic Activation of a Symbiosis-regulated Truffle Phospholipase A2Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cellsProduction of Furin-Cleaved Papillomavirus Pseudovirions and Their Use for In Vitro Neutralization Assays of L1- or L2-Specific AntibodiesFunctional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1Functional organization of the sortilin Vps10p domain.Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furinFunctional analysis of the cucumisin propeptide as a potent inhibitor of its mature enzyme.EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APPSmall-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment.Identification of a pH sensor in the furin propeptide that regulates enzyme activationInsights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furinThe microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus.Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation.The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin.Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation.Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.Structure-function analysis of the prosegment of the proprotein convertase PC5A.Propeptides as modulators of functional activity of proteases.The metalloprotease of Listeria monocytogenes is regulated by pH.A novel subtilase inhibitor in plants shows structural and functional similarities to protease propeptides.Lysosomotropic drugs inhibit maturation of transforming growth factor-beta.A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step.
P2860
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P2860
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The ordered and compartment-sp ...... equired for enzyme activation.
@ast
The ordered and compartment-sp ...... equired for enzyme activation.
@en
type
label
The ordered and compartment-sp ...... equired for enzyme activation.
@ast
The ordered and compartment-sp ...... equired for enzyme activation.
@en
prefLabel
The ordered and compartment-sp ...... equired for enzyme activation.
@ast
The ordered and compartment-sp ...... equired for enzyme activation.
@en
P2093
P2860
P921
P3181
P356
P1476
The ordered and compartment-sp ...... equired for enzyme activation.
@en
P2093
Eric D Anderson
François Jean
Gary Thomas
Satoko Shimamura
Sean S Molloy
P2860
P304
12879-12890
P3181
P356
10.1074/JBC.M108740200
P407
P577
2002-01-17T00:00:00Z