Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
about
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-KitCandidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarraysReceptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cellsStructural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificityGermline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosisGab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-KitKIT associated intracellular tyrosines play an essential role in EpoR co-signalingIdentification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.An oriented peptide array library (OPAL) strategy to study protein-protein interactions.Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand.Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase.Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicleNormal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML.Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.Molecular mechanisms utilized by alternative c-kit gene products in the control of spermatogonial proliferation and sperm-mediated egg activation.The testicular germ cell tumour genome.Role of intracellular tyrosines in activating KIT-induced myeloproliferative diseaseA Novel Molecular and Functional Stemness Signature Assessing Human Cord Blood-Derived Endothelial Progenitor Cell Immaturity.Grb10 and Grb14: enigmatic regulators of insulin action--and more?Stem cell factor expression, mast cells and inflammation in asthma.Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders.A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis.Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesisA survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer.Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis.Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways.Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression.The human kinome and kinase inhibition.Autophosphorylation of KITGRB2:SOS interacts with p-KITInteraction of other adapter proteins with p-KITThe scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
P2860
Q24535600-99CE943F-D47C-49F5-8410-4B141A78C73FQ24550972-4671C506-D3AA-4BC8-A11B-A43D3BE1079EQ26740953-C07670F9-BFC0-4940-8EE4-7B9BDA463A57Q27640366-DFA7951F-0935-4156-A955-30478126285FQ28080034-20F522CB-A8BA-460B-829B-DCC9D2331E52Q28115545-B6881646-017A-4FBA-A84F-CAF8C464CC5EQ28588986-E2DEA472-95DB-417B-892B-E71A96DA1A71Q31036345-6209FEA3-ED00-433F-9C0C-FDB16532A485Q31538849-9A35E93C-05C8-456F-9407-76C369E42128Q33196000-D82E1C4F-0D77-4101-B399-25179276EFF5Q34130780-E0D2655E-0373-4221-ACF4-5FEC2CFC8891Q34150271-79FC69C2-713C-4A07-AFD2-52DEB5D32D5CQ34586752-88A9532A-F0D9-4497-91B6-1F1B6FAF2948Q34924495-B3EFB7A9-8403-494C-8013-1906348F67A5Q34943036-14F57354-6641-4C2F-B8E6-F2DF2081F29CQ35056767-00FEA909-1FF5-4426-85B5-E632CA9CC1EEQ35129484-A2A788AB-0143-4B58-8246-CD6A180C7AF2Q35230318-AC0E2CDA-E315-489D-99E1-4F2E1FDA403DQ35979075-F527B58A-0116-439D-800E-161237BF6BEAQ36131371-456CB753-9F34-4492-AE06-5B925A3C9FEAQ36382616-0D7AFBA7-AE2B-4ED4-B6D9-8E633013AA89Q36842503-DA3D6803-8217-4B72-808C-0D79BF013815Q37240757-3492CA9D-8E85-4D83-8DF5-E6723F02D453Q37307359-CB769EA3-4186-43B5-A284-F0E7E2538A2EQ37339045-9F61147D-F78B-42BB-BDD7-45BCD0B2B680Q38341206-C7D460BE-BB3E-4DD7-906B-0CCF614CE642Q39030506-529E8BF8-0315-4685-96D4-95C036221AB0Q39401758-DFD86527-DFF3-4536-ADC9-0B8E5C682749Q40266580-58498FC1-19B0-4610-94FB-97E9C49C7EDEQ40468905-75CE54A6-A95E-4BA7-B86A-47443AB04316Q40555586-AB202066-D0A7-47AE-A4CA-50493A3760A8Q40683030-F51EAB61-69C0-4FD3-ABFC-66354F2DFD66Q41813361-43580A38-2565-43F3-B0D7-F9D6CF09D671Q42001617-716F5363-08D5-4560-B71B-AA67DAC0AE64Q42036557-CE21A133-6353-4944-B771-8460CD92A5C1Q42781600-C5B174E7-061E-4EFD-9EA6-06735EE6E8C6Q50297944-61C9D733-C41F-465F-9271-71C6807DBD88Q50297952-6850B003-942F-45CA-A36F-DF79D9D87775Q50297966-96E5D544-45E4-46EE-A7B3-1B389EC334B7Q50336720-675965D4-C102-430B-BA08-29EA532DBCB0
P2860
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@ast
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@en
type
label
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@ast
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@en
prefLabel
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@ast
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@en
P2093
P2860
P3181
P1433
P1476
Identification of Tyr-703 and ...... -Kit/stem cell factor receptor
@en
P2093
Johan LENNARTSSON
Kerstin THÖMMES
Lars RÖNNSTRAND
Monika CARLBERG
P2860
P3181
P356
10.1042/0264-6021:3410211
P407
P577
1999-07-01T00:00:00Z