Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. - Wikidata - wikimedia - TriplyDB

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

http://www.wikidata.org/entity/Q30167578

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Function, regulation and pathological roles of the Gab/DOS docking proteins Structure and function of Gab2 and its role in cancer (Review)Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells Zinc is a novel intracellular second messenger Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5 Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response.The Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation.The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells Interstitial cells: regulators of smooth muscle function.A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave.Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.Abnormal hematopoiesis in Gab2 mutant mice Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells.Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.Peripheral blood gene expression profiling in rheumatoid arthritis.Conformational recognition of an intrinsically disordered protein.The stem cell factor (SCF)/c-KIT signalling in testis and prostate cancer.Gab adapter proteins as therapeutic targets for hematologic disease.Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit.Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling Selective RNAi-mediated inhibition of mutated c-kit.

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

http://www.wikidata.org/entity/Q30167578

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

@ast

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

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type

label

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

@ast

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

@en

prefLabel

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

@ast

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

@en

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.

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Eiichi Morii

http://www.w3.org/2001/XMLSchema#string

Katsuhiko Ishihara

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Keigo Nishida

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Lin Wang

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Masahiro Fujishima

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Masahiro Narimatsu

http://www.w3.org/2001/XMLSchema#string

Satoru Yamasaki

http://www.w3.org/2001/XMLSchema#string

Shousaku Itoh

http://www.w3.org/2001/XMLSchema#string

Sung Joo Park

http://www.w3.org/2001/XMLSchema#string

Toshio Hirano

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1866-1869

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scholarly article

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5

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