c-Cbl-mediated regulation of LAT-nucleated signaling complexes - Wikidata - wikimedia - TriplyDB

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

http://www.wikidata.org/entity/Q30480971

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Ubiquitylation-dependent downregulation of Nck regulates its functional activity T cell activation New Insights into How Trafficking Regulates T Cell Receptor Signaling Ubiquitin signaling in immune responses Super-resolution characterization of TCR-dependent signaling clusters WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.Proteomic characterization of plasma membrane-proximal T cell activation responses.Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b.Organization of proximal signal initiation at the TCR:CD3 complex.TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction.Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.Endocytic events in TCR signaling: focus on adapters in microclusters Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation Imaging techniques for assaying lymphocyte activation in action.TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter Overexpression of X-linked genes in T cells from women with lupus A new look at T cell receptor signaling to nuclear factor-κB Origin of the sharp boundary that discriminates positive and negative selection of thymocytes Signal initiation in T-cell receptor microclusters.Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.A conformational change within the WAVE2 complex regulates its degradation following cellular activation Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy.The LAT story: a tale of cooperativity, coordination, and choreography.Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.

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P2860

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

http://www.wikidata.org/entity/Q30480971

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

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c-Cbl-mediated regulation of LAT-nucleated signaling complexes

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type

label

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

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c-Cbl-mediated regulation of LAT-nucleated signaling complexes

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prefLabel

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

@ast

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

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P1433

Molecular and Cellular Biology

P1476

c-Cbl-mediated regulation of LAT-nucleated signaling complexes

@en

P2093

Amrita Goyal

http://www.w3.org/2001/XMLSchema#string

Connie L Sommers

http://www.w3.org/2001/XMLSchema#string

Lakshmi Balagopalan

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Lawrence E Samelson

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Matthew S Isakowitz

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Valarie A Barr

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P2860

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

cbl-3: a new mammalian cbl family protein

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

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8622-8636

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scholarly article

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10.1128/MCB.00467-07

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P433

24

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P478

27

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Mira Barda-Saad

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2007-10-15T00:00:00Z

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5907649

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17938199

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2169400

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