Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine - Wikidata - wikimedia - TriplyDB

Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine

Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine

http://www.wikidata.org/entity/Q37168519

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Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia.Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines.Nicotinic acetylcholine receptors modulate osteoclastogenesis The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site.Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists.Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin.Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicoti The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism 3-(2,4-dimethoxybenzylidene)-anabaseine: a promising candidate drug for Alzheimer's disease?Pharmacokinetic Limitations on Effects of an Alpha7 Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended Release Formulation.Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.Calcium preconditioning triggers neuroprotection in retinal ganglion cells.Working with OpusXpress: methods for high volume oocyte experiments.A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons

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P2860

Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine

http://www.wikidata.org/entity/Q37168519

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Activation and desensitization ...... idene anabaseines and nicotine

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Activation and desensitization ...... dene anabaseines and nicotine.

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type

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Activation and desensitization ...... idene anabaseines and nicotine

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Activation and desensitization ...... dene anabaseines and nicotine.

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prefLabel

Activation and desensitization ...... idene anabaseines and nicotine

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Activation and desensitization ...... dene anabaseines and nicotine.

@nl

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JPET.108.150151

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Journal of Pharmacology and Experimental Therapeutics

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Activation and desensitization ...... idene anabaseines and nicotine

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P2093

Ferenc Soti

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Gretchen Y López-Hernández

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Nicole A Horenstein

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Roger L Papke

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William R Kem

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P2860

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

Seizures increase acetylcholine and choline concentrations in rat brain regions

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors

Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment.

The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).

Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers.

Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression.

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo.

Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

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791-807

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scholarly article

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10.1124/JPET.108.150151

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2009-02-17T00:00:00Z

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24021645

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19223664

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2672872

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