PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.
about
Characterization of uncultivable bat influenza virus using a replicative synthetic virusOne health, multiple challenges: The inter-species transmission of influenza A virusKey molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virusIn vitro exposure system for study of aerosolized influenza virusTwo years after pandemic influenza A/2009/H1N1: what have we learned?Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: potential emergence of drug-resistant and virulent variantsSelection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza virusesPB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.Influenza A virus infections in swine: pathogenesis and diagnosis.Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmissionMutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence.Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cellsMammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus.Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in JapanMultiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsReversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic VirusReduction of Neuraminidase Activity Exacerbates Disease in 2009 Pandemic Influenza Virus-Infected Mice.Biological characterization of highly pathogenic avian influenza H5N1 viruses that infected humans in Egypt in 2014-2015.PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivoReassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriersMutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in miceEngineering temperature sensitive live attenuated influenza vaccines from emerging viruses.Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation.Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in miceCharacterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case.H5N1 pathogenesis studies in mammalian models.Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrierSequencing viral genomes from a single isolated plaque.Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A virusesAsparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus.Characterization of Novel Reassortant Influenza A (H5N2) Viruses Isolated from Poultry in Eastern China, 2015.Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals.PB2 segment promotes high-pathogenicity of H5N1 avian influenza viruses in mice.Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice.Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation
P2860
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P2860
PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@ast
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@en
type
label
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@ast
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@en
prefLabel
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@ast
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@en
P2093
P2860
P50
P356
P1433
P1476
PB2 residue 158 is a pathogeni ...... 5 influenza a viruses in mice.
@en
P2093
P2860
P304
P356
10.1128/JVI.01694-10
P577
2010-10-20T00:00:00Z