Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions.
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Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's diseasePhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Exploring the accessible conformations of N-terminal acetylated α-synucleinAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersMysterious oligomerization of the amyloidogenic proteinsDopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse.Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).Thiol-redox signaling, dopaminergic cell death, and Parkinson's diseaseIntracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sitesStructural and functional properties of prefibrillar α-synuclein oligomersModulating protein activity and cellular function by methionine residue oxidation.α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Structural, morphological, and functional diversity of amyloid oligomers.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Biophysical Characterization of α-Synuclein and Rotenone Interaction.Reactivity of copper-α-synuclein peptide complexes relevant to Parkinson's disease.Dietary Modulation of Oxidative Stress in Alzheimer's Disease.Conformational dynamics of α-synuclein: insights from mass spectrometry.Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein.An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation.Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein.Autophagy enhancement is rendered ineffective in presence of α-synuclein in melanoma cells.UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent α-synuclein oligomers.Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration.Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and FreezingAlpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study
P2860
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P2860
Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Methionine oxidation stabilize ...... cular long-range interactions.
@ast
Methionine oxidation stabilize ...... cular long-range interactions.
@en
type
label
Methionine oxidation stabilize ...... cular long-range interactions.
@ast
Methionine oxidation stabilize ...... cular long-range interactions.
@en
prefLabel
Methionine oxidation stabilize ...... cular long-range interactions.
@ast
Methionine oxidation stabilize ...... cular long-range interactions.
@en
P2093
P2860
P1476
Methionine oxidation stabilize ...... cular long-range interactions.
@en
P2093
Anthony L Fink
Chunmei Long
Donato A Di Monte
Stephen H Reaney
Wenbo Zhou
P2860
P304
P356
10.1016/J.BBADIS.2009.12.004
P407
P577
2009-12-21T00:00:00Z