Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.
about
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseNovel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal modelsDevelopment of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsNovel M(1) allosteric ligands: a patent review.Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling.Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model.Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
P2860
Q28660933-0E1125BF-0ACF-4D0D-BC55-E3C47670D997Q36099440-F593D006-80EA-4444-BF3A-2265A02DDE59Q37025888-2DBDECD3-2ECC-408A-B095-8EABF1C0ED70Q38054855-62BB5D9D-67D5-4ED7-8551-78089ADEF0C7Q38070176-C40ABD69-D840-4167-B83E-1BC6A08067B6Q39077987-703F066E-A490-472D-87B3-7484F9569B95Q39222571-D14AE39D-096A-4ABA-A6F0-783FF4996409Q42093765-2DC47614-74E4-4648-86DA-EA9704F56415Q42154556-3CE52E0A-374C-4243-BFBE-3F40621253ACQ48203728-56962671-9BD4-4E1C-8C52-8C3A80382BC6Q50694188-00BC3FEA-5828-40F9-923C-46DB0592C2CB
P2860
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Development of a highly select ...... ed from the MLPCN probe ML071.
@en
type
label
Development of a highly select ...... ed from the MLPCN probe ML071.
@en
prefLabel
Development of a highly select ...... ed from the MLPCN probe ML071.
@en
P2093
P2860
P1476
Development of a highly select ...... ed from the MLPCN probe ML071.
@en
P2093
Bruce J Melancon
Douglas J Sheffler
Evan P Lebois
Gregory J Digby
Hyekyung P Cho
J Scott Daniels
James C Tarr
Michael R Wood
Nicole R Miller
Ryan Morrison
P2860
P304
P356
10.1016/J.BMCL.2011.08.084
P407
P577
2011-08-24T00:00:00Z