Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. - Wikidata - wikimedia - TriplyDB

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

http://www.wikidata.org/entity/Q30490028

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Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network.Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Coupling viruses to dynein and kinesin-1 The axonal transport of mitochondria Huntington's disease: underlying molecular mechanisms and emerging concepts JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells Mitochondrial trafficking in neurons PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy Interrogating Emergent Transport Properties for Molecular Motor Ensembles: A Semi-analytical Approach Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Axonal transport and neurodegenerative disease: can we see the elephant?Motor domain phosphorylation modulates kinesin-1 transport Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT Identification of molecular motors in the Woods Hole squid, Loligo pealei: an expressed sequence tag approach.The BioAssay network and its implications to future therapeutic discovery.GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies Therapeutic approaches to preventing cell death in Huntington disease Targets for future clinical trials in Huntington's disease: what's in the pipeline?JNK regulates FoxO-dependent autophagy in neurons Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

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P2860

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

http://www.wikidata.org/entity/Q30490028

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

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Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

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Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

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Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

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Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

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Nature Neuroscience

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Pathogenic huntingtin inhibits ...... 3 and phosphorylating kinesin.

@en

P2093

Agnieszka Kaminska

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Benny Björkblom

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Carolina Bagnato

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Chun-Fang Huang

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David Han

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Eleanor T Coffey

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Gary Banker

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Gerardo A Morfini

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Gustavo Pigino

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Katherine Liu

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P2860

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Selective interaction of JNK protein kinase isoforms with transcription factors

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

X-ray structure of motor and neck domains from rat brain kinesin

Axonal transport defects: a common theme in neurodegenerative diseases

Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry.

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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864-871

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10.1038/NN.2346

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7

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26291598

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19525941

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phosphorylation

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2739046

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