Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
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Structural Basis for the Identification of the N-Terminal Domain of Coronavirus Nucleocapsid Protein as an Antiviral TargetSmall-molecule inhibitors of the Rce1p CaaX proteaseAllylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide IsosteresPhosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based AssaysDiscovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic ShuttlingPhotooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase.Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione.The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases.Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core StructureDual-specificity phosphatases as targets for antineoplastic agents.Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cellsThe suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNAA quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.Targeting the PTPome in human disease.CDC25 phosphatases in cancer cells: key players? Good targets?Is Cdc25 a druggable target?Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.Switching Futile para-Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin-Specific Protease-2 Inhibition, Electrocatalysis, and Quantification.2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2).Multimodal control of Cdc25A by nitrosative stressDiscovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components.Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase.Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma.Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3.Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.Small-molecule inhibitors of SETD8 with cellular activity.Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations.Claspin and Chk1 regulate replication fork stability by different mechanisms.Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons.Synthesis and biological evaluation of caulibugulones A-E.CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin.Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.Quinoline and naphthalene derivatives from Saccharopolyspora sp. YIM M13568.
P2860
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P2860
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@ast
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@en
type
label
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@ast
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@en
prefLabel
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@ast
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@en
P2093
P356
P1476
Discovery and biological evalu ...... ity protein phosphatase Cdc25.
@en
P2093
Ducruet AP
Southwick EC
P304
P356
10.1021/JM0102046
P407
P577
2001-11-01T00:00:00Z