Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. - Wikidata - wikimedia - TriplyDB

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

http://www.wikidata.org/entity/Q30831287

about

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling Maintaining Genome Stability in Defiance of Mitotic DNA Damage Checkpoint kinase 1 in DNA damage response and cell cycle regulation Roles of Chk1 in cell biology and cancer therapy The role of Cdc25A in the regulation of cell proliferation and apoptosis Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A.The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.Cdc25 and the importance of G2 control: insights from developmental biology.Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.Development of synthetic lethality anticancer therapeutics.STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.Redundant pathways for Cdc2 activation in Xenopus oocyte: either cyclin B or Mos synthesis Regulation of the cellular DNA double-strand break response.Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase.From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition.Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells.DNA damage checkpoints in mammals.The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system.Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition.Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail.Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide.Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint.Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.Regulation of mitotic entry by microcephalin and its overlap with ATR signalling.Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition.The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells.MAPK pathway activation delays G2/M progression by destabilizing Cdc25B.Carboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast.The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation.

P2860

Q24314273-B7AB12E1-2918-44EA-80BF-2FDF649899E5 Q26738970-DF8D134D-9822-466E-95C1-914561460B34 Q28287480-F04140E4-9609-4E6D-A4A9-20474AA860F0 Q28289548-F4C0F664-FED1-49CD-A8E6-EACD1807FBF0 Q28611420-D7D418E1-6985-4515-A228-3BB10F7DB460 Q33578169-31C2D06F-34FA-40D4-BF94-681119E3DBA5 Q33756957-57CDCC78-E2B7-497C-9CED-D34D10548857 Q33849693-6B499193-3270-43B5-90F8-0D7E3217F18E Q33930739-390B386E-DE2A-470C-B714-CAAE19596C27 Q33952789-279E5FE1-A381-4064-8BEE-79E8E9774958 Q34181806-B9A838C5-9718-469E-89EE-55B15BD5A6D0 Q34380368-50C011D9-9669-49A6-B954-49C3C054FD37 Q34562426-D6C943E7-C26E-4AEA-BC12-B530C51D715A Q34590238-570EBECA-31C0-4216-A7BB-F9D6328C6800 Q34722112-F8D77626-49D5-4FD0-91A0-23CFC4C3F70D Q34734401-65A0EA15-073C-49D1-B49F-0348E760D42F Q35676617-DEDE4CF3-B95C-41D3-8035-852C2AC87E90 Q35794854-282DF684-A26E-49F6-A9CC-1E5B8E64FD77 Q35867102-5B2047E8-DF69-4C89-9354-53EA6369FA01 Q36254558-2BFD467B-D192-4E67-8B7B-8158F4AD271A Q36325437-EDCFD82A-4F63-484C-831E-C11A265472AB Q36685541-F3C81B50-4382-4EF9-AE30-B251DB1617F4 Q37158396-06532177-2366-406A-A741-5A0052E917B8 Q37678202-AF87BEEB-9058-4B4B-A266-5F0F45E274ED Q38268221-0EC3C283-599B-48E3-8F4F-14D3F2DF3CE2 Q38984960-A64B3C4D-4517-4988-91BE-13C944B57802 Q39038832-8515982B-15F6-4AC0-BC32-D4C871C0A4F0 Q39044559-3C5B9961-37D9-4F8B-8652-26C46DF5895E Q39570779-2CDA0793-98AD-4F4E-8203-E45DFDB05E53 Q39713463-D713D0AD-667A-49F7-B46B-F2D0CEF56239 Q39896689-5AA80F80-69F2-4DA2-B5EB-074F694DF247 Q40172266-33185D0A-86F7-4699-A7B9-E849AAEC3921 Q40265990-CD194D94-C851-4DB9-9982-2232068D1F50 Q40985225-430D9FD7-8C96-4AE1-9045-68A11B61D596 Q41155017-DBB46B38-A818-4919-A0C2-98B886480355 Q42152715-3B9CB444-2340-428F-865B-16DE6C82AAC7 Q44361179-BFD59FBF-E94C-420A-91DD-83A169FF66CB Q53119516-CD851D93-BC04-4CCC-B3B4-3500304FBB8E

P2860

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

http://www.wikidata.org/entity/Q30831287

description

2004 nî lūn-bûn

@nan

2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@ast

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@en

type

label

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@ast

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@en

prefLabel

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@ast

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@en

P1433

Q30831287-11EBB665-85D7-4149-B825-92D39A05D358

P1476

Q30831287-A7B11E89-F3D4-4E2B-9C4A-FBE6C8F98DEF

P2093

Q30831287-23762BCA-853B-419F-8B31-FA72956F9F42

Q30831287-33FA887B-2A81-4FBB-A323-6B1C21FAF64E

Q30831287-6E4A9004-BC4E-4B26-825B-21B59525719D

Q30831287-87A83A7A-85A7-4724-91E8-30C2EA72ECE8

Q30831287-97C6F5F8-F139-4CEF-95BE-20F697B47F2A

P2860

Q30831287-06F01515-762C-4902-92C8-B1ABA600CA89

Q30831287-083A48C8-6C13-4AE0-9DCF-D9E873C50F5B

Q30831287-0C2CD4A0-1595-4ADC-ACCC-4EEF1727AE19

Q30831287-0F3EC6AA-A671-46CA-A4FF-A646B0D05288

Q30831287-152BB818-8442-4904-B0BE-BB3BB397A5FA

Q30831287-189FDD80-718F-407F-95B5-CA04FBDB8EA7

Q30831287-2A70F9E0-F41F-4116-95D5-C70C4C388640

Q30831287-2B1D17F4-3271-47D9-9AF2-323B934BEB34

Q30831287-2E1BF618-E8D5-4AA8-8EA3-7CA068EF4983

Q30831287-2F7ECA1D-B057-40E7-9D38-140370EA397D

P304

Q30831287-B2D96EF4-E7A7-4C02-AD74-8B4463018E5C

P31

Q30831287-D7D1531E-F304-4591-8AA6-F2A02BD4A481

P356

Q30831287-1B055D1F-E622-4399-B1F9-F7AD851DBA1B

P407

Q30831287-088BA7F2-B32C-4D0B-AEE6-1015DFE4AA7A

P433

Q30831287-9A11AE11-6589-4266-911B-222D79EFC668

P478

Q30831287-2A6F8C7C-CE25-4DBF-B0F4-1ED0BE8C299F

P577

Q30831287-9280026E-CE0E-4B27-A6A4-8B632CC9AC9B

P5875

Q30831287-CF223157-145F-4EDA-8B38-37F843C2373E

P698

Q30831287-8166C7C0-8E14-4FF0-A2A6-5A786381E167

P932

Q30831287-81E7FCCF-D503-4676-A334-BB1DB737FFB8

P356

SJ.EMBOJ.7600328

P1433

The EMBO Journal

P1476

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

@en

P2093

Daigo Inoue

http://www.w3.org/2001/XMLSchema#string

Katsuhiro Uto

http://www.w3.org/2001/XMLSchema#string

Ken Shimuta

http://www.w3.org/2001/XMLSchema#string

Nobushige Nakajo

http://www.w3.org/2001/XMLSchema#string

Noriyuki Sagata

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Genetic control of cell division patterns in the Drosophila embryo

Checkpoints: controls that ensure the order of cell cycle events

The DNA damage response: putting checkpoints in perspective

ATM and ATR: networking cellular responses to DNA damage

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

P304

3386-3396

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.EMBOJ.7600328

http://www.w3.org/2001/XMLSchema#string

P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P577

2004-07-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8437988

http://www.w3.org/2001/XMLSchema#string

P698

15272308

http://www.w3.org/2001/XMLSchema#string

P932

514503

http://www.w3.org/2001/XMLSchema#string