Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.
about
The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signalingAS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domainAKT/PKB signaling: navigating downstreamNeuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagyUpregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture modelEffect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activityRole of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytesInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40Neuregulin signaling on glucose transport in muscle cellsSGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expressionAbsence of the lipid phosphatase SHIP2 confers resistance to dietary obesityCluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membraneMulti-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8Muscle-specific Pten deletion protects against insulin resistance and diabetesPhosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult ratsAkt2 phosphorylates ezrin to trigger NHE3 translocation and activationEstrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transportAn APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neuronsEmerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficThrombin-induced glucose transport via Src-p38 MAPK pathway in vascular smooth muscle cellsMechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted ratsPalmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells.miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing.AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cellsMiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple OncogenesAmplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.Phase I study of the anti-IGF1R antibody cixutumumab with everolimus and octreotide in advanced well-differentiated neuroendocrine tumors.Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscleDistinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.Identification of a role for CLASP2 in insulin actionInsulin signalling in human adipose tissue.A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes.Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats.
P2860
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P2860
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@ast
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@en
type
label
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@ast
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@en
prefLabel
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@ast
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@en
P2093
P2860
P921
P356
P1476
Use of RNA interference-mediat ...... B isoforms in insulin actions.
@en
P2093
Hiroshi Shiota
Kazuhiro Kishi
Norihisa Masuyama
Rie Matsushima
Takashi Katome
Toshiyuki Obata
Yousuke Ebina
Yukiko Gotoh
P2860
P304
28312-28323
P356
10.1074/JBC.M302094200
P407
P577
2003-05-06T00:00:00Z