Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.
about
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structureCrystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damageDeficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stressMinichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesImmunoglobulin class switch recombination is impaired in Atm-deficient miceHistone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response53BP1: pro choice in DNA repairThe checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNANFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage53BP1 is required for class switch recombination.microRNA-34a promotes DNA damage and mitotic catastrophe.Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 153BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in miceTopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in miceGive me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling eventsTying the loose ends together in DNA double strand break repair with 53BP1.KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining RepairSignificance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesisXRN2 Links Transcription Termination to DNA Damage and Replication Stress.The role of ATM and 53BP1 as predictive markers in cervical cancer.A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells.An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.Regulation of checkpoint kinases through dynamic interaction with Crb2.53BP1 promotes ATM activity through direct interactions with the MRN complex.Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage.The tandem BRCT domain of 53BP1 is not required for its repair function.Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability.Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis.Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.Expression pattern of p53-binding protein 1 as a new molecular indicator of genomic instability in bladder urothelial carcinoma
P2860
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P2860
Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@ast
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@en
type
label
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@ast
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@en
prefLabel
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@ast
Negative cell cycle regulation ...... ion of the BRCT protein 53BP1.
@en
P2093
P2860
P356
P1476
Negative cell cycle regulation ...... tion of the BRCT protein 53BP1
@en
P2093
P2860
P304
P356
10.1074/JBC.M007665200
P407
P577
2000-10-20T00:00:00Z