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Regulation of checkpoint kinases through dynamic interaction with Crb2.

Regulation of checkpoint kinases through dynamic interaction with Crb2.

http://www.wikidata.org/entity/Q39318591

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Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Regulatory motifs in Chk1 BRCT domains: easy as one, two, three Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment Telomeres avoid end detection by severing the checkpoint signal transduction pathway Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.ATR autophosphorylation as a molecular switch for checkpoint activation.A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast Regulation of chk1.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.

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Regulation of checkpoint kinases through dynamic interaction with Crb2.

http://www.wikidata.org/entity/Q39318591

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@en

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@nl

type

label

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@en

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@nl

prefLabel

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@en

Regulation of checkpoint kinases through dynamic interaction with Crb2.

@nl

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SJ.EMBOJ.7600018

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The EMBO Journal

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Regulation of checkpoint kinases through dynamic interaction with Crb2

@en

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Matthew J O'Connell

http://www.w3.org/2001/XMLSchema#string

Mitsuhiro Yanagida

http://www.w3.org/2001/XMLSchema#string

Nobuki Aono

http://www.w3.org/2001/XMLSchema#string

Satoru Mochida

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.

Checkpoints: controls that ensure the order of cell cycle events

ATR and ATRIP: partners in checkpoint signaling

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418-428

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scholarly article

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10.1038/SJ.EMBOJ.7600018

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2

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23

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Katsuyuki Tamai

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2004-01-22T00:00:00Z

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8905760

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