Regulation of checkpoint kinases through dynamic interaction with Crb2.
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Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4Regulatory motifs in Chk1BRCT domains: easy as one, two, threeStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentTelomeres avoid end detection by severing the checkpoint signal transduction pathwayPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeThe phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.ATR autophosphorylation as a molecular switch for checkpoint activation.A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombeThe Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeastRegulation of chk1.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeastHMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.
P2860
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P2860
Regulation of checkpoint kinases through dynamic interaction with Crb2.
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2004 nî lūn-bûn
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2004年の論文
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Regulation of checkpoint kinases through dynamic interaction with Crb2.
@en
Regulation of checkpoint kinases through dynamic interaction with Crb2.
@nl
type
label
Regulation of checkpoint kinases through dynamic interaction with Crb2.
@en
Regulation of checkpoint kinases through dynamic interaction with Crb2.
@nl
prefLabel
Regulation of checkpoint kinases through dynamic interaction with Crb2.
@en
Regulation of checkpoint kinases through dynamic interaction with Crb2.
@nl
P2093
P2860
P356
P1433
P1476
Regulation of checkpoint kinases through dynamic interaction with Crb2
@en
P2093
Matthew J O'Connell
Mitsuhiro Yanagida
Nobuki Aono
Satoru Mochida
P2860
P304
P356
10.1038/SJ.EMBOJ.7600018
P407
P577
2004-01-22T00:00:00Z