Yeast screen for constitutively active mutant G protein-activated potassium channels.
about
A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.A discrete alcohol pocket involved in GIRK channel activationInward rectifiers and their regulation by endogenous polyaminesCrystal structure of a Kir3.1-prokaryotic Kir channel chimeraIdentification of yeast proteins necessary for cell-surface function of a potassium channel.Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channelsSelection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine blockVitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding proteinFunctional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domainsSearching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133Controlling potassium channel activities: Interplay between the membrane and intracellular factors.Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesisThe pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices.A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesTandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.Using yeast to study potassium channel function and interactions with small molecules.Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channelPotential use of potassium efflux-deficient yeast for studying trafficking signals and potassium channel functions.Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.Overexpression of membrane proteins from higher eukaryotes in yeasts.Multiple modalities converge on a common gate to control K2P channel function.Gating mechanism of KATP channels: function fits form.Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase CYeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate.Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels.A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 ChannelsA cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels.Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreElectrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gatingConformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels.Evolving potassium channels by means of yeast selection reveals structural elements important for selectivityElucidation of the gating of the GIRK channel using a spectroscopic approach.
P2860
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P2860
Yeast screen for constitutively active mutant G protein-activated potassium channels.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@ast
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@en
type
label
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@ast
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@en
prefLabel
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@ast
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@en
P2093
P1433
P1476
Yeast screen for constitutively active mutant G protein-activated potassium channels.
@en
P2093
P304
P356
10.1016/S0896-6273(01)00241-0
P407
P577
2001-03-01T00:00:00Z