The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
about
IMP dehydrogenase: structure, mechanism, and inhibition.Ribavirin contributes to eradicate hepatitis C virus through polarization of T helper 1/2 cell balance into T helper 1 dominanceReduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug ResistanceA heterocyclic molecule with significant activity against dengue virusThe Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor SelectivityA cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5AThe antibiotic potential of prokaryotic IMP dehydrogenase inhibitorsAdvances in Nuclear Magnetic Resonance for Drug Discovery.Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.Expression of IMPDH mRNA after mycophenolate administration in male volunteers.Mycophenolate mofetil and FK506 have different effects on kidney allograft fibrosis in rats that underwent chronic allograft nephropathy.Mechanisms of action of ribavirin in antiviral therapies.Host-based ribavirin resistance influences hepatitis C virus replication and treatment response.The quest for an efficacious antiviral for respiratory syncytial virus.In silico design of human IMPDH inhibitors using pharmacophore mapping and molecular docking approachesProduction of indole antibiotics induced by exogenous gene derived from sponge metagenomes.Challenges for the development of ribonucleoside analogues as inducers of error catastrophe.Chronic hepatitis C and no response to antiviral therapy: potential current and future therapeutic options.Novel pharmacological approaches in the treatment of psoriasis.Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.Treating viral hepatitis C: efficacy, side effects, and complications.Antiviral treatment of hepatitis C.Present and future therapy for hepatitis C virus.Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.Role of ribavirin in HCV treatment response: now and in the future.Host cell factors as antiviral targets in arenavirus infection.Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients.Hypoxanthine-guanine phosphoribosyltransferase and inosine 5'-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa).Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment.Mycophenolic acid inhibits replication of Type 2 Winnipeg, a cerebrospinal fluid-derived reovirus isolate.Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions.Two lessons from the interface of genetics and medicine.IMPDHII protein inhibits Toll-like receptor 2-mediated activation of NF-kappaB.Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies.Hepatitis C virus free-virion and immune-complex dynamics during interferon therapy with and without ribavirin in genotype-1b chronic hepatitis C patients.Ribavirin modulates the conversion of human CD4(+) CD25(-) T cell to CD4(+) CD25(+) FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell.Synthesis and biological activities of 2-functionalized purine nucleosides.
P2860
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P2860
The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@ast
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@en
type
label
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@ast
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@en
prefLabel
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@ast
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@en
P1433
P1476
The structure of inosine 5'-mo ...... he design of novel inhibitors.
@en
P2093
Nimmesgern E
Sintchak MD
P304
P356
10.1016/S0162-3109(00)00193-4
P577
2000-05-01T00:00:00Z