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Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

http://www.wikidata.org/entity/Q32121511

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alpha-Synuclein and neuronal cell death Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study Dynamic structural flexibility of α-synuclein Neuropathological alterations in Alzheimer disease Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1 Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.Biophysics of α-synuclein membrane interactions.Widespread alterations of alpha-synuclein in multiple system atrophy Evaluation of alpha-synuclein immunohistochemical methods used by invited experts α-Synuclein oligomers impair neuronal microtubule-kinesin interplay.An scFv intrabody against the nonamyloid component of alpha-synuclein reduces intracellular aggregation and toxicity Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.The chaperone-like activity of α-synuclein attenuates aggregation of its alternatively spliced isoform, 112-synuclein in vitro: plausible cross-talk between isoforms in protein aggregation.Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Late-onset neurodegenerative diseases--the role of protein insolubility.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Lewy bodies.Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases Cell-specific post-transcriptional regulation of γ-synuclein gene by micro-RNAs.Accumulation of NACP/alpha-synuclein in lewy body disease and multiple system atrophy Lewy body cortical involvement may not always predict dementia in Parkinson's disease.Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.alpha-synuclein promotes mitochondrial deficit and oxidative stress Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.

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P2860

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

http://www.wikidata.org/entity/Q32121511

description

1998 nî lūn-bûn

@nan

1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի փետրվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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type

label

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

@ast

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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prefLabel

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

@ast

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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The American Journal of Pathology

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Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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P2093

A Takeda

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E Masliah

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L Hansen

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M Mallory

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P2860

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

The rat brain synucleins; family of proteins transiently associated with neuronal membrane.

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system.

Identification of two distinct synucleins from human brain.

Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.

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neurodegeneration

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1857971

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