Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.
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Transiently transfected purine biosynthetic enzymes form stress bodiesParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelDynamic structural flexibility of α-synucleinNeuropathology in mice expressing mouse alpha-synucleinSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyExcess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein.Protein misfolding specifies recruitment to cytoplasmic inclusion bodiesUbiquitin conjugating enzymes participate in polyglutamine protein aggregation.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formationSpecificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers.Recent advances in our understanding of neurodegeneration.Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron deathΑ-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cellsThe North American Multiple System Atrophy Study Group.Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Nurr1 in Parkinson's disease and related disorders.Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive elementSynthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cellsUnbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.The Synucleinopathies: Twenty Years On.Protein aggregation in Parkinson's disease.Chemistry and biology of the ubiquitin signal.New insight into neurodegeneration: the role of proteomics.Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.
P2860
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P2860
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@ast
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@en
type
label
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@ast
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@en
prefLabel
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@ast
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@en
P2093
P2860
P1476
Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.
@en
P2093
Aaron C Pawlyk
Benoit I Giasson
Deepak M Sampathu
Virginia M-Y Lee
P2860
P304
P356
10.1016/S0002-9440(10)63633-4
P407
P577
2003-07-01T00:00:00Z