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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

http://www.wikidata.org/entity/Q33180485

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Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis Using animal models to determine the significance of complement activation in Alzheimer's disease Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42 Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.The nerve growth factor signaling and its potential as therapeutic target for glaucoma Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.Neuroplasticity in Alzheimer's disease.NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology Neurotrophins and neurodegenerative diseases: receptors stuck in traffic?Neurotrophins and neurodegeneration.Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease NGF, brain and behavioral plasticity.TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells.Current advances in using neurotrophic factors to treat neurodegenerative disorders Nerve growth factor, neural stem cells and Alzheimer's disease.Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease.Cytoskeletal transport in the aging brain: focus on the cholinergic system.Immunosympathectomy as the first phenotypic knockout with antibodies.NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons.Phenserine.Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.NGF and proNGF Reciprocal Interference in Immunoassays: Open Questions, Criticalities, and Ways Forward.Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke.The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.A hypnic hypothesis of Alzheimer's disease.

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P2860

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

http://www.wikidata.org/entity/Q33180485

description

2000 nî lūn-bûn

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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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PNAS.97.12.6826

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

@en

P2093

A Cattaneo

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A Comparini

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G Ugolini

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N Berardi

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P2860

Neuropathological stageing of Alzheimer-related changes

The cholinergic hypothesis of geriatric memory dysfunction

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Muscular dystrophy in adult and aged anti-NGF transgenic mice resembles an inclusion body myopathy.

Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy.

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Transgenic animals in Alzheimer's disease research.

Neurodegenerative tauopathies: human disease and transgenic mouse models.

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

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12

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97

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12475890

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10841577

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Alzheimer's disease

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18754

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