The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
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DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingNuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusionEpigenetic principles and mechanisms underlying nervous system functions in health and diseaseDYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionDesign and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsdDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome micePotent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeDown syndrome--recent progress and future prospects.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression.The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes.Lack of evidence for direct phosphorylation of recombinantly expressed P2X(2) and P2X (3) receptors by protein kinase C.Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis.Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples.Mechanism of dual specificity kinase activity of DYRK1A.The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism.Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin.Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency
P2860
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P2860
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@ast
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@en
type
label
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@ast
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@en
prefLabel
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@ast
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@en
P2093
P2860
P50
P356
P1433
P1476
The protein kinase DYRK1A phos ...... l in vivo phosphorylation site
@en
P2093
Hanna Czajkowska
Katrin de Graaf
Len C Packman
Sabine Rottmann
P2860
P2888
P356
10.1186/1471-2091-7-7
P577
2006-03-02T00:00:00Z
P5875
P6179
1004409111