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Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceSignaling by the phosphoinositide 3-kinase family in immune cellsAKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alphaTemporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cellsPI3Ks in lymphocyte signaling and developmentNon-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.Critical roles of the PI3K/Akt signaling pathway in T cell developmentThe microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1.The coordination of T-cell function by serine/threonine kinases.Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases.Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Deletion of PKBalpha/Akt1 affects thymic development
@ast
Deletion of PKBalpha/Akt1 affects thymic development
@en
Deletion of PKBalpha/Akt1 affects thymic development.
@nl
type
label
Deletion of PKBalpha/Akt1 affects thymic development
@ast
Deletion of PKBalpha/Akt1 affects thymic development
@en
Deletion of PKBalpha/Akt1 affects thymic development.
@nl
prefLabel
Deletion of PKBalpha/Akt1 affects thymic development
@ast
Deletion of PKBalpha/Akt1 affects thymic development
@en
Deletion of PKBalpha/Akt1 affects thymic development.
@nl
P2093
P2860
P1433
P1476
Deletion of PKBalpha/Akt1 affects thymic development
@en
P2093
Brian A Hemmings
Debby Hynx
Elisabeth Fayard
Georg A Holländer
Magdalena Paolino
P2860
P356
10.1371/JOURNAL.PONE.0000992
P407
P50
P577
2007-10-03T00:00:00Z