Consequences of GATA-1 deficiency in megakaryocytes and platelets.
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Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoproteinA critical role for the transcription factor Scl in platelet production during stress thrombopoiesisThe TR2 and TR4 orphan nuclear receptors repress Gata1 transcriptionX-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interactionOsteoimmunology: interactions of the bone and immune systemCyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidizationThe contribution of mouse models to the understanding of constitutional thrombocytopeniaPluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical applicationThe secret life of a megakaryocyte: emerging roles in bone marrow homeostasis controlAutophagy driven by a master regulator of hematopoiesisInsights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysisZinc finger protein, Hzf, is required for megakaryocyte development and hemostasisMaturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteinsGeneration and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndromeTranslational isoforms of FOG1 regulate GATA1-interacting complexesThe critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cellsSynergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA.Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation.Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signalingExpression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and developmentA mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturationTransient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cellsMechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4.Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.Concomitant a novel ALAS2 mutation and GATA1 mutation in a newborn: a case report and review of the literature.Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytesThe transcription factor GATA1 regulates NBEAL2 expression through a long-distance enhancer.GATA factor mutations in hematologic disease.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosisPathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.
P2860
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P2860
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@ast
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@en
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@nl
type
label
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@ast
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@en
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@nl
prefLabel
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@ast
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@en
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@nl
P2093
P1433
P1476
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
@en
P2093
P304
P407
P577
1999-05-01T00:00:00Z