Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. - Wikidata - wikimedia - TriplyDB

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

http://www.wikidata.org/entity/Q33329474

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Chemical Variations on the p53 Reactivation Theme Targeting Oncogenic Mutant p53 for Cancer Therapy Tumor suppressor p53 and its gain-of-function mutants in cancer Smoking, p53 mutation, and lung cancer Small molecule compounds targeting the p53 pathway: are we finally making progress?Structural evolution of p53, p63, and p73: Implication for heterotetramer formation Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73 The rebel angel: mutant p53 as the driving oncogene in breast cancer.JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo p73 as a pharmaceutical target for cancer therapy Targeting p53 for Novel Anticancer Therapy.Pathologies associated with the p53 response.Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G₂/M checkpoint signaling.Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells p53 Family and Cellular Stress Responses in Cancer.Targeting p53 by small molecules in hematological malignancies.p73 in Cancer.Translational approaches targeting the p53 pathway for anti-cancer therapy.Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53.Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.Mutant p53: one name, many proteins.Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73 Therapeutic targeting of the p53 pathway in cancer stem cells.Therapeutic prospects for p73 and p63: rising from the shadow of p53.Pharmacological activation of p53 in cancer cells Targeting the p53 pathway.Targeting cancer stem cells with p53 modulators.Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes.Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.p53 family: Therapeutic targets in neuroblastoma.p53-based cancer therapy p53-targeted cancer pharmacotherapy: move towards small molecule compounds.The TP73 complex network: ready for clinical translation in cancer?The aggregation of mutant p53 produces prion-like properties in cancer.The clinical development of p53-reactivating drugs in sarcomas - charting future therapeutic approaches and understanding the clinical molecular toxicology of Nutlins.Mutant p53 in cancer: new functions and therapeutic opportunities.A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.Pharmacological reactivation of p53 as a strategy to treat cancer.

P2860

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P2860

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

http://www.wikidata.org/entity/Q33329474

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway.

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PNAS.0802091105

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Proceedings of the National Academy of Sciences of the United States of America

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Small-molecule RETRA suppresse ...... p73-dependent salvage pathway

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A V Gudkov

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D V Kochetkov

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E Feinstein

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E I Frolova

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E Strom

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G V Ilyinskaya

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I Kovriga

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J E Kravchenko

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L S Agapova

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P G Komarov

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P2860

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

The antioxidant function of the p53 tumor suppressor

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

ASPP: a new family of oncogenes and tumour suppressor genes.

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

p73: a chiaroscuro gene in cancer.

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.

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6302-6307

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scholarly article

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10.1073/PNAS.0802091105

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17

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105

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Peter M. Chumakov

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2008-04-18T00:00:00Z

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5427350

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18424558

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2327210

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