Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.
about
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradationThe great escape: viral strategies to counter BST-2/tetherinThe formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to VpuHIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactionsHIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiencyStructural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomainThe restriction factors of human immunodeficiency virusHow SAMHD1 changes our view of viral restrictionHIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanismsDifferential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherinBST-2/tetherin: a new component of the innate immune response to enveloped virusesAntiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteractionHIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomesThe role of BST-2/Tetherin in host protection and disease manifestationTetherin restricts productive HIV-1 cell-to-cell transmissionConformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral ActivityCullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexCharacterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentivirusesIntrinsic cellular defenses against human immunodeficiency virusesCounteraction of the multifunctional restriction factor tetherinDual host-virus arms races shape an essential housekeeping proteinTwo-stepping through time: mammals and virusesEvolutionary dynamics of the interferon-induced transmembrane gene family in vertebratesCounteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu geneEvolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replicationThe HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonismTetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.Modulation of HIV-1-host interaction: role of the Vpu accessory proteinAnalysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin.HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef.Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.Ultra structural characterisation of tetherin - a protein capable of preventing viral release from the plasma membraneA Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.CAML does not modulate tetherin-mediated restriction of HIV-1 particle releaseAntagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartmentThe RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherinProteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication.Novel approaches to inhibiting HIV-1 replication.Positive selection of primate genes that promote HIV-1 replication.Molecular evolution of the primate antiviral restriction factor tetherin
P2860
Q21089617-0B68CE9F-E028-4020-8070-B9C46BD355B5Q21090506-223E24D0-3925-4CD9-9AFA-B40892FA330FQ21245050-5B4D9098-08A0-4760-B262-8B6C0690ADEBQ24296630-B034DDA5-4695-4642-8910-98C4038521EEQ24300016-8F11C3C7-F5D9-43D5-BE40-F985079385DFQ24306855-F113BE09-0952-4A82-9C80-35C435695A6FQ24605108-4653F619-8929-44AE-856B-B2E6E19A1847Q24605899-A593775C-C390-46FF-80A6-0AB60A947892Q24619066-7ED7A691-2C74-4941-BF59-375EB34D9C77Q24629504-E6330326-670E-474D-9D1D-22A8589CBF43Q24630382-ABC1458A-7BB4-4526-9A0A-09EA25578486Q24635271-80880C04-9F5B-4997-9195-47C26064C356Q24646984-99C54065-2BE9-480B-9212-9D5140A3F314Q26752737-282E96C9-B7D9-4EA1-AAA6-42A4B6C4C04DQ27314339-1A1E1C70-D30F-4533-BAB7-935F6DB860E9Q27664241-C9D97E2B-0BD7-4F18-A6D8-7D5FB5D14156Q28237912-1F448543-01A0-4925-A4C7-84F6579B01ACQ28656415-2D62B285-BC97-4F72-9889-2BE1078E138CQ28659575-0C733B03-1754-4B33-A05D-A90FC7CEB8DFQ28659945-D42D1659-D86E-49A0-92D0-58CDF6EBA851Q28686764-11801540-DFDA-4828-B6CB-2F704D8162A7Q28709092-5D213823-EEA4-4F9D-A5AF-420628F9DEF9Q28712012-7ABFFD9E-DEAE-41C9-9DE7-0741ECE92F4AQ28730542-2E1C55B2-92B5-49E6-B4C2-CBA16748DC66Q28742565-5B5F82D7-934A-4844-B174-3D88A1141C13Q28742774-C33A20BA-8188-4CE8-B586-9CCFC6B8C648Q30382590-F42F13CD-FE0B-4466-81FC-2C15C2764CE2Q30397761-8EA1C246-273B-44AD-8841-8494E23F2D35Q30406836-44093010-9410-48B8-991E-C595FFB91D18Q30410687-CD514C6C-E7A2-40B9-A2EE-6C88549F66FCQ30425799-8C153CA8-F3D7-491D-B58B-43A3ED9802CDQ31034125-9049285C-9AF5-407D-9321-0376024019A1Q33292303-9483A7D1-0863-42EC-9B9D-AB11B36955E5Q33528976-B8778575-329E-43A0-86D7-28B05ECB95E8Q33553369-6E38B356-F43E-469F-8634-04CDDCBC17CDQ33564429-2D45B23B-61A0-4805-854E-D97E55D31F91Q33589167-45F35AA2-C3CC-4048-A083-FE507B7903F5Q33624690-5B9FDAE2-F3A7-4BFE-815A-5385B4C0435BQ33637979-AFD5CCEB-9DCD-45E0-A29D-5C61A3938F13Q33650914-E30D2EA0-0081-43CB-AC53-2A31306EEF5C
P2860
Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@ast
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@en
type
label
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@ast
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@en
prefLabel
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@ast
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@en
P2093
P2860
P50
P1433
P1476
Mutation of a single residue r ...... HIV-1 Vpu-mediated depletion.
@en
P2093
Ernst Verschoor
Greg J Towers
Ravindra K Gupta
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000443
P577
2009-05-22T00:00:00Z