Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.
about
Recent progress in structure-based anti-influenza drug designStructural basis for the function and inhibition of an influenza virus proton channelStructure of the amantadine binding site of influenza M2 proton channels in lipid bilayersInhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assayThe Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic ResonanceStructures of influenza A proteins and insights into antiviral drug targets.Membrane protein structure and dynamics from NMR spectroscopy.Structure and dynamic properties of membrane proteins using NMR.Structural basis for proton conduction and inhibition by the influenza M2 protein.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Coexistence of two adamantane binding sites in the influenza A M2 ion channel.Proton and cation transport activity of the M2 proton channel from influenza A virus.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesA pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 proteinHydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors.Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activityDiscovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.Structure and function of the influenza A M2 proton channelStructural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virusSlow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction.Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel.Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors.Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness.Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.Effects of amantadine on the dynamics of membrane-bound influenza A M2 transmembrane peptide studied by NMR relaxation.Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy.
P2860
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P2860
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@ast
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@en
type
label
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@ast
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@en
prefLabel
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@ast
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@en
P2093
P2860
P50
P356
P1476
Discovery of spiro-piperidine ...... hannel from influenza A virus.
@en
P2093
Lawrence H Pinto
Victoria Balannik
P2860
P304
P356
10.1021/JA900063S
P407
P577
2009-06-01T00:00:00Z