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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

http://www.wikidata.org/entity/Q36455201

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Rapalogs in cancer prevention: anti-aging or anticancer?Advances in targeting signal transduction pathways Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis Rapamycin extends murine lifespan but has limited effects on aging.Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice Latest progress in tyrosine kinase inhibitors Survival rates of homozygotic Tp53 knockout rats as a tool for preclinical assessment of cancer prevention and treatment eRapa restores a normal life span in a FAP mouse model.Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration.From rapalogs to anti-aging formula.In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.Dietary energy balance modulates ovarian cancer progression and metastasis.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugs Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/b1 integrin signaling activation.Gerosuppression in confluent cells.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life Primed for cancer: Li Fraumeni Syndrome and the pre-cancerous niche p53 and rapamycin are additive.Geroconversion: irreversible step to cellular senescence Comparison of rapamycin schedules in mice on high-fat diet.Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Rejuvenating immunity: "anti-aging drug today" eight years later.Koschei the immortal and anti-aging drugs A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet.mTORC1 and p53: clash of the gods?Recent discoveries in the cycling, growing and aging of the p53 field Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.Li Fraumeni syndrome, cancer and senescence: a new hypothesis.

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P2860

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

http://www.wikidata.org/entity/Q36455201

description

2012 nî lūn-bûn

@nan

2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@ast

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@en

type

label

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@ast

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@en

prefLabel

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@ast

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

@en

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

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P2093

Andrei V Gudkov

http://www.w3.org/2001/XMLSchema#string

Elena A Komarova

http://www.w3.org/2001/XMLSchema#string

Geraldine Paszkiewicz

http://www.w3.org/2001/XMLSchema#string

Liliya R Novototskaya

http://www.w3.org/2001/XMLSchema#string

Marina P Antoch

http://www.w3.org/2001/XMLSchema#string

Olga B Chernova

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Olga V Leontieva

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P2860

Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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709-714

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10.18632/AGING.100498

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10

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4

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Mikhail Blagosklonny

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2012-10-01T00:00:00Z

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23123616

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3517941

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