alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.
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Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerizationStimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3βParkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitrop25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathiesSecondary structure and dynamics of micelle bound beta- and gamma-synucleinThe potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's diseaseStructures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formationSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsMicrotubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filamentsAlpha-synuclein and tau: teammates in neurodegeneration?Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsα-Synuclein oligomers impair neuronal microtubule-kinesin interplay.Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Self-oligomerization and protein aggregation of alpha-synuclein in the presence of Coomassie Brilliant Blue.Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease.High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.Roles of tau protein in health and disease.Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseAssociation of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.Neuroproteomics as a promising tool in Parkinson's disease research.Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.Organization and functional roles of the cytoskeleton in oligodendrocytes.Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein.Concerted perturbation observed in a hub network in Alzheimer's diseaseIron and Parkinson's disease.Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathyA powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration.Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.Is tau a suitable therapeutical target in tauopathies?Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson's Disease.Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of GuamQuantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal FluidThe microtubule-associated protein tau is phosphorylated by SykLewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology.Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis.The Differences between Blast-Induced and Sports-Related Brain Injuries
P2860
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P2860
alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@ast
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@en
type
label
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@ast
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@en
prefLabel
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@ast
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@en
P2093
P356
P1476
alpha-synuclein binds to Tau a ...... f serine residues 262 and 356.
@en
P2093
P304
25481-25489
P356
10.1074/JBC.274.36.25481
P407
P577
1999-09-01T00:00:00Z