The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
about
Chk1 suppressed cell deathHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityOkazaki fragment processing-independent role for human Dna2 enzyme during DNA replicationManaging Single-Stranded DNA during Replication Stress in Fission YeastRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseA dual role for A-type lamins in DNA double-strand break repairRFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing off.Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repairReplication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.DNA structure-specific priming of ATR activation by DNA-PKcs53BP1 promotes microhomology-mediated end-joining in G1-phase cells.Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae.The DNA damage response and checkpoint adaptation in Saccharomyces cerevisiae: distinct roles for the replication protein A2 (Rfa2) N-terminus.The mTOR inhibitor rapamycin suppresses DNA double-strand break repairA dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cellsHomologous recombination and its regulationTRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expressionThe role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapyControlling DNA-end resection: a new task for CDKs.Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer.p53 suppresses hyper-recombination by modulating BRCA1 function.Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress.DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.Artemis-dependent DNA double-strand break formation at stalled replication forks.A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation.Transcriptional activation of p21Waf1 contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin.
P2860
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P2860
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The role of RPA2 phosphorylati ...... response to replication arrest
@ast
The role of RPA2 phosphorylati ...... response to replication arrest
@en
The role of RPA2 phosphorylati ...... esponse to replication arrest.
@nl
type
label
The role of RPA2 phosphorylati ...... response to replication arrest
@ast
The role of RPA2 phosphorylati ...... response to replication arrest
@en
The role of RPA2 phosphorylati ...... esponse to replication arrest.
@nl
prefLabel
The role of RPA2 phosphorylati ...... response to replication arrest
@ast
The role of RPA2 phosphorylati ...... response to replication arrest
@en
The role of RPA2 phosphorylati ...... esponse to replication arrest.
@nl
P2093
P2860
P356
P1433
P1476
The role of RPA2 phosphorylati ...... response to replication arrest
@en
P2093
Ignacio Gonzalez-Suarez
Jiuqin Zhang
Joseph L Roti Roti
Junran Zhang
Robert P Vanderwaal
Simon N Powell
Xiaohua Wu
Zhihui Feng
P2860
P304
P356
10.1093/CARCIN/BGQ035
P407
P577
2010-02-03T00:00:00Z