Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. - Wikidata - wikimedia - TriplyDB

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

http://www.wikidata.org/entity/Q33535647

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Emerging Treatment Paradigms in Radiation Oncology ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients.Casein kinase 1δ-dependent Wee1 protein degradation.Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy WEE1 tyrosine kinase, a novel epigenetic modifier Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer.Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6 Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells The fork and the kinase: a DNA replication tale from a CHK1 perspective.A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations.The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition The ATR barrier to replication-born DNA damage.Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase.Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.SUMO2/3 modification of cyclin E contributes to the control of replication origin firing.A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity Wee1 kinase as a target for cancer therapy.Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.Beyond ATM: the protein kinase landscape of the DNA damage response.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.Replication fork dynamics and the DNA damage response.Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst.

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P2860

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

http://www.wikidata.org/entity/Q33535647

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Regulators of cyclin-dependent ...... g genome integrity in S phase.

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Journal of Cell Biology

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P2093

Halfdan Beck

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Michael Lees

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Petra Groth

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Randi G Syljuåsen

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Viola Nähse

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P2860

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Cytoscape: a software environment for integrated models of biomolecular interaction networks

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

Cell-cycle checkpoints and cancer

The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability

BIND: the Biomolecular Interaction Network Database

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

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629-638

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10.1083/JCB.200905059

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5

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188

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Thomas Helleday

Mette Jørgensen

Marie Sofie Yoo Larsen

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2010-03-01T00:00:00Z

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41656762

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20194642

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2835936

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