about
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875Glucose-stimulated insulin response in pregnant sheep following acute suppression of plasma non-esterified fatty acid concentrationsTranscriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell functionPotential roles of GPR120 and its agonists in the management of diabetesEndoplasmic reticulum stress and type 2 diabetesChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsGPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetesLipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipidsChaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpressionThe CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic isletsUnsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome.Central role of the adipocyte in the metabolic syndrome.Macrophages transfer [14C]-labelled fatty acids to pancreatic islets in culture.Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.T cells cooperate with palmitic acid in induction of beta cell apoptosis.Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.Weight loss therapy improves pancreatic endocrine function in obese older adultsNonlinear modeling of the dynamic effects of infused insulin on glucose: comparison of compartmental with Volterra modelsInadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes MellitusIdentification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase.The relevance of the glycaemic index to our understanding of dietary carbohydrates.Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysisReactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerolRegulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human isletsFree fatty acids--do they play a central role in type 2 diabetes?Redefining the clinical management of type 2 diabetes: matching therapy to pathophysiology.Yi-Qi-Zeng-Min-Tang, a Chinese medicine, ameliorates insulin resistance in type 2 diabetic rats.Effects of free fatty acids on insulin secretion in obesity.Adiposity and β-cell function: relationships differ with ethnicity and ageLiver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons.The role of European genetic admixture in the etiology of the insulin resistance syndrome in children: are the effects mediated by fat accumulation?
P2860
Q24301044-AA77205D-B310-421A-A568-DDE9CEEEFC1FQ24795251-CCCD25F5-BF2D-4657-8CEF-4F2E38CC9D75Q24803245-CC805AAF-BDB4-4819-8575-D619ECB937F6Q26827101-9AA587FD-5E28-4636-A3B1-C43EA04440B4Q26864238-0E8DCB5A-3C8F-424D-8407-CA6525D03663Q27316876-FA4A1F2C-B75D-4522-9EBF-32A358862463Q27865189-EB8ADAB1-60CB-4CAC-9F39-557F26D470D7Q27865234-A9A06127-945B-4B21-84CB-FC225C89D9F0Q28218908-D44A54F3-7B05-4DB4-ACEB-99587FF397B2Q28361455-788D0690-C1E1-4FE0-8A14-0F0818AFC3BEQ28540631-C35C50D5-5EDE-4C4C-8812-B2E96FA9FB5DQ28572048-AF20D5CA-135A-4AC5-A893-18B1072ED887Q30478807-1CCBDDAC-0F3A-4F23-8C2B-7DAB70EE31A2Q32056560-AA1FA3E1-49DE-47F0-82C9-ACD83C994D52Q32063456-16A64821-FA8D-48A7-9AAE-9F433DC69C3DQ33184238-E3E4AF73-316C-4256-99D4-D8A0B62223C2Q33302249-725E4E61-E275-4726-82AA-D0FF32E3A31AQ33334424-F34A56A6-8766-4A47-B754-318D06C775A1Q33451028-A991A430-DD56-4E5C-BA18-9247C851F47EQ33493414-E4EAF57B-219D-4285-953C-4BA0B006FF52Q33558075-7AD03D1C-F51E-4D4F-9FB7-F472CD8B6256Q33565059-1FEF6C1B-C7C0-43D7-AB3A-45F5039F62C6Q33649718-322676E0-D3F7-4E62-956A-22D8C941C377Q33775600-18CD4069-5F4A-415B-ABF7-6AB6CC9BA091Q33848857-F4925855-61A2-4275-92E5-EEA39FD503C2Q33953674-858D634E-94EE-4CB4-A4DD-B83CC500C850Q34122480-69980876-A77B-4648-9A28-3D6819B6D1AAQ34137563-4F99D948-BED3-4200-9767-D98F0B90440EQ34207748-A476875C-719D-4EF7-A23F-11FC1BEA08AFQ34212667-10ECE576-38AB-4871-B705-F20087305C9FQ34312182-846D11BD-3D2F-43D5-A30C-8C2C1D657A3BQ34332162-1F3830B7-DBA1-4BBB-8492-E2BB2CF1E82FQ34422774-52A6056B-1922-47AE-B0DC-63EED978F543Q34655587-E5A1C59C-201A-4E00-96D1-B44BE7DC7C60Q34671018-F8516550-A014-47AF-B175-B7DFC23C9A47Q34743351-8174726A-F361-4087-9531-9E42333DF15DQ34781467-A2773631-C4C7-4D1A-B307-D782BFC34D24Q34835012-4EC7BB64-5C91-4B51-ABCD-66B3EF09BC78Q34940128-B6C030A7-BA7D-425D-A54F-ED18808DC92EQ35059159-EE902874-41A5-4544-8373-9363BF4DEB6B
P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Fatty acids, lipotoxicity and insulin secretion.
@ast
Fatty acids, lipotoxicity and insulin secretion.
@en
Fatty acids, lipotoxicity and insulin secretion.
@nl
type
label
Fatty acids, lipotoxicity and insulin secretion.
@ast
Fatty acids, lipotoxicity and insulin secretion.
@en
Fatty acids, lipotoxicity and insulin secretion.
@nl
prefLabel
Fatty acids, lipotoxicity and insulin secretion.
@ast
Fatty acids, lipotoxicity and insulin secretion.
@en
Fatty acids, lipotoxicity and insulin secretion.
@nl
P356
P1433
P1476
Fatty acids, lipotoxicity and insulin secretion.
@en
P2093
Dobbins RL
McGarry JD
P2888
P304
P356
10.1007/S001250051130
P577
1999-02-01T00:00:00Z
P5875
P6179
1008206265