A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.
about
Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationProteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Evolutionary history and functional characterization of the amphibian xenosensor CAR.Activation of xenobiotic receptors: driving into the nucleus.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptorDifferential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineMulti-species analyses of direct activators of the constitutive androstane receptor.CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Compartment-specific gene regulation of the CAR inducer efavirenz in vivo.The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cellsQuantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines.Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling
P2860
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P2860
A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A single amino acid controls t ...... nsitive splicing variant CAR3.
@ast
A single amino acid controls t ...... nsitive splicing variant CAR3.
@en
A single amino acid controls t ...... nstitutive androstane receptor
@nl
type
label
A single amino acid controls t ...... nsitive splicing variant CAR3.
@ast
A single amino acid controls t ...... nsitive splicing variant CAR3.
@en
A single amino acid controls t ...... nstitutive androstane receptor
@nl
prefLabel
A single amino acid controls t ...... nsitive splicing variant CAR3.
@ast
A single amino acid controls t ...... nsitive splicing variant CAR3.
@en
A single amino acid controls t ...... nstitutive androstane receptor
@nl
P2093
P2860
P356
P1476
A single amino acid controls t ...... nsitive splicing variant CAR3.
@en
P2093
Gregory Kim
Haishan Li
Hongbing Wang
Leslie M Tompkins
Yuxin Zheng
P2860
P304
P356
10.1124/JPET.109.159210
P407
P577
2009-10-09T00:00:00Z