Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
about
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionSEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationHacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming StrategyThe SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansNeddylation dysfunction in Alzheimer's disease.The message and the messenger: delivering RNA in neurons.A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23Dying for a cause: invertebrate genetics takes on human neurodegeneration.Fbw7/hCDC4 dimerization regulates its substrate interactionsNotch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegansspr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein.The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans.The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.Where Notch and Wnt signaling meet. The presenilin hubMedical significance of Caenorhabditis elegans.Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.Cell cycle. Archipelago of destruction.A partnership that delivers.
P2860
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P2860
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@ast
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@en
type
label
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@ast
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@en
prefLabel
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@ast
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@en
P2093
P2860
P356
P1476
Evidence for functional and ph ...... protein, and SEL-12 presenilin
@en
P2093
E J Hubbard
I Greenwald
J K Kitajewski
P2860
P304
15787-15791
P356
10.1073/PNAS.95.26.15787
P407
P577
1998-12-01T00:00:00Z