FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. - Wikidata - wikimedia - TriplyDB

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

http://www.wikidata.org/entity/Q33648263

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Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Novel bile acid therapeutics for the treatment of chronic liver diseases Fibroblast Growth Factor Signaling in Metabolic Regulation Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.Fundamentals of FGF19 & FGF21 action in vitro and in vivo Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways Therapeutic utilities of fibroblast growth factor 19.Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).The Fibroblast Growth Factor signaling pathway Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease.FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis.Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes.Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma.Advances in pharmacotherapy for primary biliary cirrhosis.The structural biology of the FGF19 subfamily FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation.Modulation of fibroblast growth factor 19 expression by bile acids, meal replacement and energy drinks, milk, and coffee.Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment.Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma.Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer.Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition Association between fibroblast growth factor receptor-4 gene polymorphism and risk of prostate cancer: a meta-analysis.Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma.The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target.Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target.Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease.Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action IL-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes.Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma.Cardiac actions of fibroblast growth factor 23.Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma.Sulfated glycosaminoglycan-assisted receptor specificity of human fibroblast growth factor (FGF) 19 signaling in a mouse system is different from that in a human system.Hepatocellular carcinoma treatment: a comparative review of emerging growth factor receptor antagonists.Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.

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P2860

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

http://www.wikidata.org/entity/Q33648263

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

@wuu

name

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@ast

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@en

type

label

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@ast

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@en

prefLabel

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@ast

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@en

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JBC.M109.068783

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Journal of Biological Chemistry

P1476

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

@en

P2093

Bryan Lemon

http://www.w3.org/2001/XMLSchema#string

Hongfei Ge

http://www.w3.org/2001/XMLSchema#string

Jamila Gupte

http://www.w3.org/2001/XMLSchema#string

Jennifer Weiszmann

http://www.w3.org/2001/XMLSchema#string

Randy Hecht

http://www.w3.org/2001/XMLSchema#string

Richard Lindberg

http://www.w3.org/2001/XMLSchema#string

Steven Vonderfecht

http://www.w3.org/2001/XMLSchema#string

Todd Hager

http://www.w3.org/2001/XMLSchema#string

Xinle Wu

http://www.w3.org/2001/XMLSchema#string

Yang Li

http://www.w3.org/2001/XMLSchema#string

P2860

C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Liver-specific activities of FGF19 require Klotho beta

FGF-21 as a novel metabolic regulator.

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

Actions and mode of actions of FGF19 subfamily members

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease.

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.

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8

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285

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2009-12-15T00:00:00Z

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20018895

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2820743

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