Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. - Wikidata - wikimedia - TriplyDB

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

http://www.wikidata.org/entity/Q42542192

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Notch signaling: its roles and therapeutic potential in hematological malignancies Signaling in T cells - is anything the m(a)TOR with the picture(s)?mTOR kinase inhibitors as potential cancer therapeutic drugs Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth.mTOR signaling, Tregs and immune modulation.Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.mTOR Links Environmental Signals to T Cell Fate Decisions.Mtor-Fanconi Anemia DNA Damage Repair Pathway in Cancer.Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.Rictor is required for early B cell development in bone marrow.mTOR and metabolic regulation of conventional and regulatory T cells.Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination A critical role for Rictor in T lymphopoiesis.Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancer.Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells.Requirement for Rictor in homeostasis and function of mature B lymphoid cells.Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.mTOR and metabolic pathways in T cell quiescence and functional activation.Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway.Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.mTOR, metabolism, and the regulation of T-cell differentiation and function.Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis.Regulation of T cells by mTOR: the known knowns and the known unknowns.Evolving perspectives of mTOR complexes in immunity and transplantation.mTOR signaling and transcriptional regulation in T lymphocytes mTORC signaling in hematopoiesis.Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.mTORC1 and mTORC2 in cancer and the tumor microenvironment.

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P2860

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

http://www.wikidata.org/entity/Q42542192

description

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2012年の論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

@en

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

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type

label

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

@en

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

@nl

prefLabel

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

@en

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

@nl

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Journal of Experimental Medicine

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Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

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Emmanuel Volanakis

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Jin Chen

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Keunwook Lee

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Ki Taek Nam

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Prathyusha Gudapati

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Ross Potter

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Sung Hoon Cho

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Yoonha Hwang

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

The PI3K-PDK1 connection: more than just a road to PKB

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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713-728

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10.1084/JEM.20111470

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4

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209

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