ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
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Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis.The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpointInhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fatTea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study.A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair.Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.A novel topical targeting system of caffeine microemulsion for inhibiting UVB-induced skin tumor: characterization, optimization, and evaluation.Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells.Targeting protective autophagy exacerbates UV-triggered apoptotic cell deathCaffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated miceThe Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes.The ATR barrier to replication-born DNA damage.ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.Mechanisms of Caffeine-Induced Inhibition of UVB CarcinogenesisHeterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells.Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibitionEvidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1γH2Ax: biomarker of damage or functional participant in DNA repair "all that glitters is not gold!".Coffee Consumption and Melanoma: A Systematic Review and Meta-Analysis of Observational Studies.ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin.The effects of caffeine on wound healing.The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma.Caffeine intake and risk of basal cell and squamous cell carcinomas of the skin in an 11-year prospective study.A New Way to Treat Brain Tumors: Targeting Proteins Coded by Microcephaly Genes?: Brain tumors and microcephaly arise from opposing derangements regulating progenitor growth. Drivers of microcephaly could be attractive brain tumor targets.
P2860
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P2860
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@ast
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@en
type
label
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@ast
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@en
prefLabel
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@ast
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@en
P2093
P2860
P356
P1476
ATR-Chk1 pathway inhibition pr ...... rotective effects of caffeine.
@en
P2093
Alessandra Blasina
Allan H Conney
Kenna Anderes
Masaoki Kawasumi
Paul Nghiem
Timothy P Heffernan
P2860
P2888
P304
P356
10.1038/JID.2008.435
P407
P577
2009-02-26T00:00:00Z
P5875
P6179
1020877210