Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.
about
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Complex regulation of the human gene for the Z-DNA binding protein DLM-1.Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastIdentification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta.Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cellsMagoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.The hDcp2 protein is a mammalian mRNA decapping enzymeHuman Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structuresA novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elementsNovel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesCytoplasmic foci are sites of mRNA decay in human cellsDcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathwayIntegration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastThe DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation.Novel G-protein complex whose requirement is linked to the translational status of the cell.Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans.The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiaeUpstream open reading frames as regulators of mRNA translation.Saturation mutagenesis of 5S rRNA in Saccharomyces cerevisiae.The Y14 protein communicates to the cytoplasm the position of exon-exon junctionsPoly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation.Nonsense-mediated decay mutants do not affect programmed -1 frameshiftingAminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation systemNonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitutionThe role of Upf proteins in modulating the translation read-through of nonsense-containing transcriptsNonsense-mediated mRNA decay in Saccharomyces cerevisiae: a quality control mechanism that degrades transcripts harboring premature termination codons.Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegansA high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.Premature termination codons enhance mRNA decapping in human cells.NMD: a multifaceted response to premature translational termination.Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.Kinetics of ribosomal pausing during programmed -1 translational frameshifting.Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicingRegulation of calpain and calpastatin in differentiating myoblasts: mRNA levels, protein synthesis and stability.Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.
P2860
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P2860
Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Should we kill the messenger? ...... termination and mRNA turnover.
@ast
Should we kill the messenger? ...... termination and mRNA turnover.
@en
type
label
Should we kill the messenger? ...... termination and mRNA turnover.
@ast
Should we kill the messenger? ...... termination and mRNA turnover.
@en
prefLabel
Should we kill the messenger? ...... termination and mRNA turnover.
@ast
Should we kill the messenger? ...... termination and mRNA turnover.
@en
P2093
P2860
P1433
P1476
Should we kill the messenger? ...... termination and mRNA turnover.
@en
P2093
Czaplinski K
González CI
Ruiz-Echevarria MJ
P2860
P304
P356
10.1002/(SICI)1521-1878(199908)21:8<685::AID-BIES8>3.0.CO;2-4
P407
P577
1999-08-01T00:00:00Z