Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping. - Wikidata - wikimedia - TriplyDB

Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.

Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.

http://www.wikidata.org/entity/Q38614772

about

Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes Structural characterization of the Rous sarcoma virus RNA stability element A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p Translation initiation factor eIF3 promotes programmed stop codon readthrough.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Targeting of aberrant mRNAs to cytoplasmic processing bodies.Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells General translational repression by activators of mRNA decapping Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae.High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection.Nonsense-mediated mRNA decapping occurs on polyribosomes in Saccharomyces cerevisiae Nuclear expression of a group II intron is consistent with spliceosomal intron ancestry.Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.When a ribosome encounters a premature termination codon.Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors.Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae Nonsense-mediated decay mutants do not affect programmed -1 frameshifting The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.Deciphering the rules by which 5'-UTR sequences affect protein expression in yeast.Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.Analysis of P-body assembly in Saccharomyces cerevisiae How do trypanosomes change gene expression in response to the environment?A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay.Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells.Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae.Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain Messenger RNA regulation: to translate or to degrade.Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping Early nonsense: mRNA decay solves a translational problem.Rules of UGA-N decoding by near-cognate tRNAs and analysis of readthrough on short uORFs in yeast A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells.Protecting the proteome: Eukaryotic cotranslational quality control pathways.

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P2860

Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.

http://www.wikidata.org/entity/Q38614772

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1999 nî lūn-bûn

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1999年學術文章

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Recognition of yeast mRNAs as ...... the control of mRNA decapping.

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Recognition of yeast mRNAs as ...... the control of mRNA decapping.

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Molecular Biology of the Cell

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Recognition of yeast mRNAs as ...... the control of mRNA decapping.

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Muhlrad D

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Parker R

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P2860

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.

Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript

Turnover mechanisms of the stable yeast PGK1 mRNA

A perfect message: RNA surveillance and nonsense-mediated decay

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure

Premature translational termination triggers mRNA decapping

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10.1091/MBC.10.11.3971

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