The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts
about
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decayCharacterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.The effect of eukaryotic release factor depletion on translation termination in human cell linesBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayInteraction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysIdentification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.Termination of translation: interplay of mRNA, rRNAs and release factors?FLU: a negative regulator of chlorophyll biosynthesis in Arabidopsis thalianaSplicing enhances translation in mammalian cells: an additional function of the exon junction complexMechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylasesRibosome-based quality control of mRNA and nascent peptidesProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsCrystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastFine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome.Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stabilityYeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastEbs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiaeNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryRibosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae.In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisChemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiaeRapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathwayPlanar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.The major 5' determinant in stop codon read-through involves two adjacent adeninesInactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptakeTranslational competence of ribosomes released from a premature termination codon is modulated by NMD factors.Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiaeMouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo.Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1
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P2860
The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The role of Upf proteins in mo ...... onsense-containing transcripts
@ast
The role of Upf proteins in mo ...... onsense-containing transcripts
@en
The role of Upf proteins in mo ...... onsense-containing transcripts
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type
label
The role of Upf proteins in mo ...... onsense-containing transcripts
@ast
The role of Upf proteins in mo ...... onsense-containing transcripts
@en
The role of Upf proteins in mo ...... onsense-containing transcripts
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prefLabel
The role of Upf proteins in mo ...... onsense-containing transcripts
@ast
The role of Upf proteins in mo ...... onsense-containing transcripts
@en
The role of Upf proteins in mo ...... onsense-containing transcripts
@nl
P2093
P2860
P356
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P1476
The role of Upf proteins in mo ...... onsense-containing transcripts
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P2093
P2860
P304
P356
10.1093/EMBOJ/20.4.880
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2001-02-01T00:00:00Z